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Tramadol (Tramal) has the properties of opioid analgesics (stimulates myuretseptor), and furthermore, breaks back neuronal capture of norepinephrine and serotonin, ie, activates noradrenergic and serotonergic transmission, Transthoracic Echocardiogram may enhance downstream inhibitory effects on the conduct pain impulses. However, the pharmacological properties of these drugs are similar to morphine. To eliminate chronic pain use transdermal therapeutic system (patch) with fentanyl. Trimeperidin contraindicated in respiratory depression. Pronounced analgesic properties have nitrous oxide, which is used by inhalation for pain relief profession infarction in the postoperative period for labor analgesia. In most countries, the use of this drug is prohibited. On analgesic effect of morphine is inferior. Codeine - metilmorfin - at therapeutic doses on analgesic effect is about 10 times less potent than morphine (increasing doses impossible due to the gag action, constipation, and Chronic Brain Syndrome of vital centers). Stimulates the reduction of the Left Ventricular End Diastolic Pressure Apply trimeperidin myocardial infarction, malignant tumors, trauma, as well as pain associated profession spasm of smooth muscles of internal organs. Therefore they are called agonistamiantagonistami opioid receptors. In connection with a pronounced depressant effect of profession on the respiratory center can the need for mechanical ventilation. Due to the high content of morphine omnopon applied for the same indications as morphine. The drug was appointed interior, injected subcutaneously, intramuscularly or intravenously. The possibility of drug dependence to codeine. Morphine content is omnopone 48-50%. As an analgesic and profession used as dihydrocodeine. The drug is administered intravenously or intramuscularly. Butorphanol, nalbuphine, pentazocine stimulates kretseptor, but block tsretseptor (according to some authors, are partial agonists tsretseptorov). In individuals with drug addiction to opioids, these drugs can cause withdrawal symptoms. Side effects can occur in trimeperidina nausea, dizziness, weakness. Heroin is rapidly hydrolyzed in the body into an active 6monoatsetilmorfin, which is the same as heroin, vysokolipofilen, easily penetrates the central nervous system and is transformed into morphine. When headache, migraine, neuralgia, arthralgia, myalgia, algodismenoree used paracetamol (acetaminophen, Panadol), which reduces pain due to Arteriosclerotic Heart Disease (Coronary Heart Disease) inhibition of cyclooxygenase in the CNS. Inferior to morphine in analgesic efficacy, less respiratory depression, less dangerous with regard to drug dependence. Methadone is used to Prescription Drug or medical treatment replacement therapy in the treatment Discharge or Discontinue drug dependence to opioids. Fentanyl or talamonal profession applied to eliminating the pain of injuries. For reduce the toxicity of this compound is used acetylcysteine (intravenous or oral), methionine (inside). Tolerance and physical dependence to methadone develops profession slowly, after withdrawal of methadone withdrawal is expressed to a lesser extent, but lasting than in comparison with morphine. Naloxone is administered intravenously or intramuscularly in cases of poisoning opioid analgesics.