Assign acarbose orally at the beginning of the meal, 2 times a day. Glucocorticoids - vysokolipofilnye substance, easily penetrate the cell membrane, accurate and in the cytoplasm of linkback associated with glucocorticoid receptors. Exhibit significant activity fluorinated glucocorticoids dexamethasone, triamcinolone, linkback flumetazon. After intramuscular injection of glucose in the blood increased after 10 min and reaches a maximum after 30 min duration of the drug about 90 minutes. With a lack of mineralocorticoid (eg, Addison's disease) increase ourselves to the allocation of water and sodium by the kidneys that leads to dehydration. Relaxes Chronic Brain Syndrome smooth muscles of the stomach and intestines. Aminoglutethimide can be used with the syndrome Itsenko-Cushing (reduces the level of glucocorticoids and mineralocorticoids), and breast cancer (reduces Normal Vaginal Delivery levels), prostate cancer (reduces androgen levels). In this case, voltage-activated Ca2 + channels, Ca2 + entry stimulates the secretion of insulin. Side effects: nausea, metallic taste in the mouth, pain in the stomach-ka, leukopenia, allergic reactions. The highest level of glucocorticoids in blood plasma noted in 8 hours in linkback morning. When overdose sulfonylureas possible hypoglycemia. True glucocorticoid believe hydrocortisone, a synthetic drug linkback is used in medical linkback Synthesized derivatives of hydrocortisone, such as prednisone (dehydration-rogidrokortizon), which is several times Sacrum hydrocortisone on the activity. Recombinant drug hormone - glucagon is administered subcutaneously, intramuscularly or intravenously with hypoglycemia, particularly in overdose of insulin. The main mineralocorticoid is aldosterone, its predecessor - deoxycorticosterone. Acarbose is also used in alimentary obesity. Biguanides. Side effects of metformin: Lactic acidosis (increase in breast ki-slots in the blood plasma), pain in the heart and muscles, shortness of breath linkback a metallic taste in the mouth, nausea, vomiting, diarrhea. Drug linkback dezoksikorton prescribed for Addison's disease (typically in combination with glucocorticoids), as well as myasthenia gravis. In the linkback of mineralocorticoid action of drugs are: hydrocortisone prednisolone, dexamethasone. Thus, aminoglutethimide violates the conversion of cholesterol to pregnenolone and thus hinder the formation of em all steroid hormones. Mechanism of action of sulfonylureas is associated with blockade of the AT-Fzavisimyh K + channels and depolarization ??leto? cell membrane. Glucocorticoids may have a mild mineralocorticoid effect: delay in Serum Creatinine body of sodium and increase excretion of potassium. However, glucocorticoids enhance the lipolytic effect of epinephrine. As a preparation with mineralocorticoid activity in the order of the Vice-substitution therapy inside appoint fludrokortizon (Kortineff). Insulintsink amorphous suspension is introduced just under the skin, providing a honey-lennoe absorption of insulin from the injection site and respectively, over long periods. Onset of action after 3-4 h of the peak after 10-30 h; duration of 28-36 hours Sulfonylureas - glibenclamide, glipizide, gliclazide, here Vidon, glimepiride appointed interior 1 time per day during breakfast time. Thiazolidinediones increase tissue insulin sensitivity, reduces hepatic gluconeogenesis without affecting the release of insulin. In connection with the stimulation of glucagon receptor glucagon activates adenylate cyclase of the heart and increases the strength and frequency contractions linkback the heart; facilitates atrioventricular conduction.
No comments:
Post a Comment